Senolytics

What are Senolytics?

Senolytics are a category of substances that have the ability to selectively eliminate senescent, or aged, cells in the body. These cells accumulate with age and contribute to a range of age-related diseases and conditions, including inflammation and reduced tissue function. By removing these cells, senolytics can potentially improve health and extend lifespan.

How do they work in the body?

Senescent cells are not dead, but they have lost their normal function and can secrete harmful substances that negatively affect neighbouring cells. Senolytics work by targeting these cells and inducing programmed cell death, leading to tissue cleansing and potentially restoring normal function in the body. Several mechanisms have been proposed, including that senolytics may affect specific signalling pathways active in senescent cells.

Scientific benefits

Several studies have investigated the effects of senolytics, and the research shows promising results. Here are some of the most studied substances:

• Fisetin: A flavonoid found in fruits such as strawberries and apples. Research has shown that fisetin can reduce the number of senescent cells and improve health in older mice.
• Quercetin: Another flavonoid found in many vegetables and fruits. Studies have shown that quercetin may have anti-inflammatory effects and can eliminate senescent cells in human cell cultures.
• Dasatinib: A cancer drug that has demonstrated senolytic effects in combination with quercetin. Research has shown that this combination can improve health in older people by reducing senescent cells.

A 2019 study published in Nature showed that treatment with senolytics can improve quality of life for older adults by reducing age-related diseases and symptoms.

Dosage and recommendations

There is currently no universal recommended dose for senolytics, as research is still in an early stage. Most studies have used doses of fisetin and quercetin between 100-500 mg per day. It is important to consult a doctor before starting any form of supplement, especially if you have underlying health conditions or are taking other medications.

Best sources and forms

Senolytics can be found in various forms, including supplements and natural foods. Here are some of the best sources:

• Fisetin: Found in strawberries, apples, grapes, and onions.
• Quercetin: Found in apples, onions, kale, and citrus fruits.
• Dasatinib: Is a prescription medication used for treating certain types of cancer and should only be used under medical supervision.

Supplements containing these substances are also available and may be an option for those wishing to increase their intake.

Side effects and warnings

Although senolytics have shown positive effects, they can also cause side effects. Common side effects of quercetin and fisetin include gastrointestinal discomfort, headaches, and allergic reactions. It is important to note that long-term use and safety of these substances are not fully established, and therefore one should always consult a doctor before starting a new supplement.

Frequently Asked Questions (FAQ)

Are senolytics safe to use?

Senolytics are generally considered safe when used at recommended doses, but it is important to consult a doctor before starting them, especially if you have underlying illnesses or are taking other medications.

Can senolytics help with age-related diseases?

Research suggests that senolytics may have the potential to improve health in older adults and reduce the risk of age-related diseases, but more research is needed to confirm these effects in humans.

How long does it take to see the effects of senolytics?

The effects of senolytics can vary depending on the individual and the type of senolytic used. Some studies have shown positive effects within a short time, while others may take longer.

Are senolytics available in foods?

Yes, senolytic compounds such as fisetin and quercetin occur naturally in many fruits and vegetables, making them part of a healthy diet.

Can I combine senolytics with other supplements?

It is always best to consult a doctor before combining different supplements, as some may interact with each other or with medications.