Fisetin

What is Fisetin?

Fisetin is a natural flavonoid found in several fruits and vegetables, especially in strawberries, apples, peaches, and kiwi. It has become known for its potential health benefits, particularly in combating the effects of ageing. Fisetin is classified as a senolytic compound, meaning it can help eliminate aged (senescent) cells in the body. This has made Fisetin one of the most promising molecules in anti-aging research.

How does it work in the body?

Fisetin acts in several ways in the body. As a strong antioxidant, it combats free radicals, which can contribute to oxidative stress and thus cellular ageing. Additionally, Fisetin has been shown to affect cell signalling and inflammation, which are central to many chronic diseases. By eliminating senescent cells, Fisetin can help improve tissue function and reduce the risk of age-related diseases.

Scientific benefits

Several studies have investigated Fisetin's effects and its potential health benefits. Here are some of the most notable findings:

• Senolytic effects: Research published in Nature has shown that Fisetin can eliminate senescent cells in mouse models, leading to improved health and lifespan.
• Neuroprotective properties: A study in the Journal of Neuroscience demonstrated that Fisetin can protect neurons against damage caused by oxidative stress, suggesting a potential role in preventing neurodegenerative diseases such as Alzheimer's.
• Anti-inflammatory effects: Fisetin has been shown to reduce inflammation in various studies, which may help lower the risk of chronic diseases.

Dosage and recommendations

There is currently no standardised dose for Fisetin, but most supplements on the market offer doses between 100 mg and 500 mg per day. It is important to consult a doctor before starting Fisetin, especially if you have underlying health conditions or are taking other medications. Research is ongoing to establish the optimal dosage and long-term effects of Fisetin.

Best sources and forms

Fisetin occurs naturally in many foods, but in relatively small amounts. Some of the best sources include:

• Strawberries
• Apples
• Peaches
• Kiwi
• Green vegetables, especially spinach and Brussels sprouts

Fisetin can also be taken as a supplement in capsule or powder form. These products are often more concentrated and can provide a higher dose than typically found in the diet.

Side effects and warnings

Fisetin is generally considered safe when taken at recommended doses. However, some individuals may experience mild side effects such as:

• Gastrointestinal discomfort
• Nausea
• Allergic reactions (rare)

It is important to be aware that more research is needed to understand the long-term effects of Fisetin, and therefore it should always be taken with caution. Pregnant or breastfeeding individuals, or those with specific medical conditions, should consult their doctor before starting Fisetin.

Frequently asked questions

What is Fisetin good for?

Fisetin is known for its antioxidant and anti-inflammatory properties, as well as its potential ability to eliminate senescent cells, which may help improve health and counteract the effects of ageing.

Can I get enough Fisetin through diet?

Although Fisetin is found in foods such as strawberries and apples, the amounts are relatively small. To achieve higher doses, supplements may be an option.

Is Fisetin safe to take?

Fisetin is generally considered safe, but it is important to follow recommended doses and consult a doctor if uncertain.

How long does it take to see effects from Fisetin?

The effects of Fisetin may vary depending on dosage and individual health status. Research is ongoing to better understand the timing of its effects.

Can I take Fisetin with other supplements?

It is best to consult a doctor before combining Fisetin with other supplements or medications to avoid potential interactions.