Nattokinase

What is Nattokinase?

Nattokinase is a fibrinolytic enzyme extracted from the traditional Japanese fermented soy product nattō. This type of soybean has been fermented using the bacterium Bacillus subtilis, resulting in a unique composition of nutrients and bioactive compounds. Nattokinase has become increasingly popular in dietary supplements and health foods, particularly due to its potential benefits for cardiovascular health. It is believed to be able to dissolve blood clots and improve blood circulation, which may contribute to better overall health.

How does it work in the body?

Nattokinase primarily works by breaking down fibrin, a protein that plays a central role in blood coagulation. When blood vessels are damaged, a chain of events is activated leading to the formation of a blood clot to stop bleeding. Nattokinase can help counteract this process by promoting fibrinolysis, which is the natural mechanism for dissolving blood clots. By increasing levels of plasmin, an enzyme that breaks down fibrin, nattokinase may contribute to improved blood flow and reduced risk of blood clots.

Scientific benefits

Several studies have investigated the potential health benefits of nattokinase. Here are some of the most prominent findings:

• Blood pressure lowering effect: Research has shown that nattokinase may help lower blood pressure in individuals with hypertension. A study published in Hypertension Research demonstrated that nattokinase supplementation led to significant reductions in both systolic and diastolic blood pressure.
• Improved circulation: Another study in the Journal of Nutritional Science and Vitaminology showed that nattokinase can improve blood circulation by reducing blood viscosity, making it easier for blood to flow through vessels.
• Anticoagulant effect: Nattokinase has been shown to have an anticoagulant effect, meaning it can inhibit the formation of blood clots. A meta-analysis of several studies published in Thrombosis Research confirmed that nattokinase significantly reduced the incidence of venous thrombosis.

Dosage and recommendations

The recommended dose of nattokinase varies depending on the product and health condition. Generally, a dose between 100–200 mg per day is recommended. It is important to consult a doctor or other healthcare professional before starting nattokinase, especially if you have a history of cardiovascular diseases or are taking blood-thinning medications.

Best sources and forms

Nattokinase is mainly available in dietary supplements in the form of capsules or tablets. It can also be found in some foods, but at much lower concentrations. The quality of nattokinase supplements can vary, so it is important to choose products from reputable manufacturers that offer third-party testing for purity and efficacy.

Side effects and warnings

Although nattokinase is generally considered safe for most people, some individuals may experience mild side effects such as gastrointestinal discomfort or diarrhoea. Because nattokinase has anticoagulant properties, people taking blood-thinning medications such as warfarin or aspirin should exercise caution and consult their doctor before starting nattokinase. Pregnant or breastfeeding women should also avoid nattokinase until more research is available.

Frequently asked questions

Is nattokinase safe to take?

Yes, for most people nattokinase is safe to take at recommended doses. However, it is always best to consult a doctor before starting any new supplement.

Can nattokinase help with high blood pressure?

Several studies have suggested that nattokinase may lower blood pressure, but more research is needed to confirm these results.

What are the most common side effects of nattokinase?

The most reported side effects include mild gastrointestinal discomfort and diarrhoea, but these are relatively uncommon.

How long does it take to see the effects of nattokinase?

The time it takes to experience the effects of nattokinase can vary depending on the individual and dosage, but many report feeling benefits within a few weeks.

Can nattokinase interact with other medications?

Yes, nattokinase can interact with blood-thinning medications, so it is important to consult a doctor if you are taking such medicines.